Much research has been published about applications of supercritical fluid technology on the preparation of nanomaterials 1820. Supercritical fluid technology an overview sciencedirect. If the temperature and pressure are both increased from stp to be at or above the critical point for. Selected for demonstration were antiinflammatory drugs ibuprofen and naproxen, for which co2 and co2cosolvent systems were used. Moreover, reducing precipitation pressure or increasing concentration. Supercritical fluid technology for drug nanoparticles. Micro and nano particles of carotenoids and biopolymers facundo mattea on. Nanoparticles in the pharmaceutical industry and the use. Supercritical fluid technology for particle engineering.
Application of supercritical fluid technology for preparation. A search conducted using scifinder scholar returned 11 907 items dealing with supercritical. The journal of supercritical fluids is an international journal devoted to the fundamental and applied aspects of pressurized substances and mixtures in the fluid state especially at conditions above the critical point including reactions, separations and chemical processes. Antioxidants free fulltext preparation and evaluation of. However, a more systematic design and manufacture of parti.
In general, the difficulties arising in the pharmaceutical industry are mostly owing to find a new method for development of novel drugs. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Major advances are needed to reduce the use of organic solvents, such as methanol, toluene, xylene, methyl ethyl ketone, and dichloromethane, which account for 27. Polymeric nanoparticles from rapid expansion of supercritical.
Formation of polymer nanoparticles in supercritical fluid jets. Micronization of cetirizine using rapid expansion of. The supercritical fluid processing technique, rapid expansion of a supercritical solution into a liquid solvent resolv, was applied to the nanosizing of waterinsoluble drug particles. Application of supercritical fluid technology for preparation of drug. In addition, close to the critical point, small changes in pressure or temperature result in large changes in. Sem images of particles in other experiments have almost the same shape, but for example in run 6, more large spherical particles were formed. Supercritical fluid technology for particle engineering ram b. Nanoparticles synthesis using supercritical fluid technology. Stanipharm supercritical fluid technology and facilities for the development and manufacturing of active pharmaceutical ingredients. Using supercritical fluid technology as a green alternative. While process conditions require high pressures, technological advances have now made it feasible to acquire such equipment for the laboratory.
Its aim is to provide a focused platform for academic and industrial researchers to publish lasting scientific. Aerogels are materials with a high microporous structure, sometimes a nanoporous structure, both with a very low bulk density. Moreover, supercritical fluid technology is very attractive for manufacturing innovative therapeutic particles, either of pure active compounds or mixtures of excipient and active. The results of 24 full factorial experiment indicated that sf nanoparticles with particle size ps from 52. Applied separations can provide you with the means to make both organic and inorganic particles. A supercritical fluid scf is any substance at a temperature and pressure above its critical point, where distinct liquid and gas phases do not exist. Microencapsulation and nanoencapsulation using supercritical. Preparation and evaluation of resveratrolloaded composite nanoparticles using a supercritical fluid technology for enhanced oral and skin delivery by eunsol ha 1, wooyong sim 1, seonkwang lee 1, jisu jeong 1, jeongsoo kim 2, inhwan baek 3, du hyung choi 4, heejun park 5, sungjoo hwang 6 and minsoo kim 1. By operating in the critical region, the pressure and temperature are used to regulate the fluid density, which, in turn, regulates the solvent power of a supercritical fluid. An overview of pharmaceutical applications bhupinder singh sekhon.
Supercritical fluid technology scft offers exciting opportunities to produce and modify pharmaceutical substances and has the potential to. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the. A simple search of the web site recently showed 92 books about supercritical fluids alone. The influences of operation parameters, including operation pressure and temperature, co2 total flow and ratio of co2 branch flow, on. The sce technology has been successfully applied at industrial scale for the. Much research has been published about applications of supercritical fluid technology on the preparation of nano materials 1820. Antioxidants free fulltext preparation and evaluation. Formation of microparticles or nanoparticles with unique morphology is the most outstanding characteristic of particle formation from supercritical fluid technology. Hydrothermal synthesis of zirconia nanocrystals in. Gupta department of chemical engineering, auburn university, auburn, alabama, u. Supercritical fluid synthesis and tribological applications. Preparation and characterization of zro2 nanoparticles by. Supercritical fluid synthesis and tribological applications of silver nanoparticledecorated graphene in engine oil nanofluid.
Supercritical fluid technology for drug nanoparticles youtube. Experimental study of nano particles formation through rapid. The materials such as nano and micro particles of high added value compounds. Cn101185868a technique for preparing lomoxicam ultra. Selected for demonstration were antiinflammatory drugs ibuprofen and naproxen, for which co 2 and co 2 cosolvent systems were used. Various supercritical particle formation technologies are briefly described, including processes in which the supercritical fluid acts as a solute, solvent, and antisolvent. Overcoming multidrug resistance through inhalable sirna. Conclusion in this work, ma particles were formed in nano scale through rapid expansion of supercritical co2 and with menthol as solid cosolvent. Eckhard weidner and marcus petermann, preparation and processing of micro and nano scale materials by supercritical fluid technology, supercritical fluid extraction of nutraceuticals and bioactive compounds, 10. Supercritical fluid scf technology is one such technique, which has become an important tool in the production of different particulate systems along with extraction and drying of protein and. Supercritical co 2 and h 2 o are extensively being used in the preparation of a great variety of nanomaterials. Pdf nanotechnology and supercritical fluids researchgate. The supercritical fluidprocessing technique, rapid expansion of a supercritical solution into a liquid solvent resolv, was applied to the nanosizing of waterinsoluble drug particles.
Keywords drug delivery systems, nanotechnologies, supercritical fluids. The aim of the study was to develop and evaluate a new method for the production of micro and nanoparticles of poorly soluble drugs for drug delivery applications. However the understanding of applying supercritical fluid technology to particle formation is still in their infancy 17. Nanoparticles in the pharmaceutical industry and the use of. It can effuse through solids like a gas, and dissolve materials like a liquid. Particle generation for pharmaceutical applications using. In the pharmaceutical industry, this technique is applied to coat the solid dosage forms, liposome formulation, and reduction of particle size. Supercritical fluids and in particular supercritical fluid carbon dioxide have shown to be a viable technology for a variety of extractions. Hydrothermal synthesis of zirconia nanocrystals in supercritical water volume 19 issue 8 yukiya hakuta, tomotugu ohashi, hiromichi hayashi, kunio arai skip to main content accessibility help we use cookies to distinguish you from other users and to provide you with a better experience on our websites.
Interest of the supercritical fluid technology for nanoparticles synthesis. Improved supercapacitor performance of mno 2graphene composites constructed using a supercritical fluid and wrapped with an ionic liquid. Supercritical fluid applications in the pharmaceutical. Unlike the traditional methods used for the particle size reduction, supercritical fluid processing techniques offer advantages ranging from superior particle size control to clean processing. When the pressure and temperature of a substance is raised above its critical pressure and critical temperature the critical point the substance enters the supercritical state. Supercritical fluid applications in the pharmaceutical industry. Supercritical fluid technologies scft represent a recent approach for obtaining pharmaceutical materials in pure physical form and the application of supercritical fluids is a superior alternative to conventional precipitation and extraction processes.
The number of applications and technologies involving supercritical fluids has also grown explosively. Composite nanoparticles using a supercritical fluid technology for enhanced oral and skin delivery eunsol ha 1, wooyong sim 1, seonkwang lee 1, jisu jeong 1, jeongsoo kim 2, inhwan baek 3, du hyung choi 4, heejun park 5, sungjoo hwang 6 and minsoo kim 1, 1 college of pharmacy, pusan national university, 63 busandaehakro, geumjeonggu. Supercritical fluid technology scft offers exciting opportunities to produce and modify pharmaceutical substances and has the. Introduction design and fabrication of pharmaceutical particulate systems is still largely an art as opposed to a fundamental science. Overcoming multidrug resistance through inhalable sirna nanoparticlesdecorated porous microparticles based on supercritical fluid technology peiyao xu, 1, 2 ranjith kumar kankala, 1, 2, 3 yujing pan, 1, 2 hui yuan, 1, 2 shibin wang, 1, 2, 3 and aizheng chen 1, 2, 3. Experimental study of nano particles formation through. Nanoparticles with supercritical fluids applied separations.
The various methods including the supercritical solution. Liposome production by scco 2 processing as aforementioned, supercritical fluid technology is an interesting alternative for the production of safer and more stable drug delivery particles. In addition, close to the critical point, small changes in pressure or temperature result in large changes in density, allowing many properties of a supercritical. Oct 23, 20 stanipharm supercritical fluid technology and facilities for the development and manufacturing of active pharmaceutical ingredients. Nanoparticles of inorganic compounds can also be produced using supercritical fluids and subcritical fluids.
Request pdf nanoparticles synthesis using supercritical fluid technology towards biomedical applications supercritical fluid scf technology has become. Hydrogen storage in graphene decorated with pd and pt nanoparticles using an electroless deposition technique. Trends in particle formation of bioactive compounds using. Zro2 nanoparticles were successfully prepared by supercritical hydrolysis in two steps hydrolysis and dehydration and were characterized by xray diffraction xrd, scanning electron microscopy sem and laser particlesize analyzer. Pratik sheth, harpreet sandhu, dharmendra singhal, waseem malick, navnit shah and m. Supercritical fluid technology is considered to be a green technology because of the environmentally benign nature of most of the supercritical fluids like scco 2. The environmental and climate program demands technological solutions in the chemical industry that incorporate prevention of pollution. Supercritical fluid technology is one of the techniques applied in the formulation of several nanoparticles with the aid of supercritical co 2 and h 2 o. Generation of silk fibroin nanoparticles via solution. Formation of polymer nanoparticles in supercritical fluid. Nanosizing drug particles in supercritical fluid processing.
Nanoparticles in the pharmaceutical industry and the use of supercritical fluid technologies for nanoparticle production volume. The solute to be precipitated is dissolved in the solvent to form a solution, and the solution is dispersed in an immiscible or partially miscible liquid to form an emulsion. Nanoparticles of poorly watersoluble drugs prepared by. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. This method takes distinguishing properties of supercritical fluids to exhibit significant solvent strength when they are compressed to liquidlike densities. A supercritical fluid is a substance with both gas and liquidlike properties. Supercritical fluid scf technology has become an important tool of materials processing in the last two decades. This technology precipitates micro14 as well as nanosized particles15 with large surface areas, controlled uniform particle sizes, and smooth surfaces,5b,14,16 which eventually augment drug bioavailability. Stabilization of proteins in dry powder formulations using. Eckhard weidner and marcus petermann, preparation and processing of micro and nanoscale materials by supercritical fluid technology, supercritical fluid extraction of nutraceuticals and bioactive compounds, 10. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the application potential of the nanoparticles, as.
Production of antibiotic micro and nanoparticles by supercritical antisolvent precipitation. Supercritical co 2 and h 2 o are extensively being used in the preparation. A supercritical fluid can be generally defined as a solvent at a temperature above its critical temperature, at which the fluid remains a single. Therapeutic proteins have become essential in the treatment of many diseases. Ppt supercritical fluid powerpoint presentation free to. The scfs advantages, benefits, and various preparation methods are discussed. Supercritical fluid technology supercritical fluid technology has been widely used for various applications such as extraction, reaction, chromatography and material processing. Overcoming multidrug resistance through inhalable sirna nanoparticles decorated porous microparticles based on supercritical fluid technology peiyao xu, 1, 2 ranjith kumar kankala, 1, 2, 3 yujing pan, 1, 2 hui yuan, 1, 2 shibin wang, 1, 2, 3 and aizheng chen 1, 2, 3.
Supercritical fluid technology scft offers exciting opportunities to produce and modify. Recent the journal of supercritical fluids articles elsevier. Thermal decomposition and hydrothermal syntheses are but two ways to accomplish this. The particles are produced via the extraction of the solvent from the emulsion using the supercritical fluid. Preparation and evaluation of resveratrolloaded composite. Supercritical carbon dioxide s co 2 is a fluid state of carbon dioxide where it is held at or above its critical temperature and critical pressure carbon dioxide usually behaves as a gas in air at standard temperature and pressure stp, or as a solid called dry ice when frozen. This technique has several advantages such as avoid the use of solvents, particles are obtained as a dry powder, instead of suspensions, mild pressure and temperature.
Ppt supercritical fluid powerpoint presentation free. The process can produce an aqueous suspension of particles that are substantially insoluble in water, and the solvents used in the process to form the emulsion initially can be recovered and recycled. However, supercritical fluid scf technology presents a new and interesting route for particle formation, which avoids most of the drawbacks of the traditional methods. Supercritical processes give micro or even nanoparticles with. Micro and nanoparticles of carotenoids and biopolymers facundo mattea on.
Traditional freezedrying or spraydrying processes are often harmful to labile proteins and could be replaced by supercritical fluid scf drying to produce particles with defined physicochemical. To overcome these drawbacks, the utilization of supercritical fluid is an alternative to produce these nanoparticles. Supercritical fluid technology is commonly utilized to prepared nanoparticles from drug solutions. Among them, supercritical fluid technology has been identified as potentially effective and applicable approach which has attracted increasing attention during recent years. Lefler, glaxosmithkline abstract direct, visual observation of materials under supercritical conditions is an important first step in the development and refinement of supercritical fluid extraction, reaction, and. Supercritical fluid technology an overview sciencedirect topics. A proper formulation and particle size is essential to obtain high colorant activity. Their formulation in dry form is often required to improve their stability. A solutionenhanced dispersion by supercritical co2 seds was employed to prepare silk fibroin sf nanoparticles. Masoud bahrami, sima ranjbarian, production of micro and nanocomposite particles by supercritical carbon dioxide, elsevier, the journal of supercritical fluids, vol. Traditional freezedrying or spraydrying processes are often harmful to labile proteins and could be replaced by supercritical fluid scf drying to produce particles with defined physicochemical characteristics in a mild single step. In the last decade, the supercritical fluid scfassisted technology generation of micro or nano particles of organic, inorganic, or their composite compounds has attracted a growing interest for increasingly sophisticated applications among scientists in various fields. Us6998051b2 particles from supercritical fluid extraction.
Winner of the standing ovation award for best powerpoint templates from presentations magazine. Applications for supercritical fluid technology production of special oils traditionally consumers have set their focus mainly in the convenience and taste of the oils. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the application potential of the nanoparticles, as their. Therefore, the supercritical fluid technology has been investigated as an alternative to prepare biodegradable micro and nanoparticles because supercritical fluids are environmentally safe 21. Carotenoid formulation is of great interest for the pharmaceutical and food industry.
346 707 207 61 861 196 1294 346 324 851 1135 1085 863 724 1380 434 766 1356 76 1575 467 578 66 758 560 1188 1510 1270 680 169 243 888 425 1488 980 971 775 989 802 1048 1229 84 1018